Pre-existing Th1 immunity is abrogated by ongoing recruitment of monocytic host cells that are refractory to activation
Matheus Batista Heitor Carneiro, Santiago Aguiar Espellet Soares, Chris Tiessen, Camila Gaio, Ben Perks, Leah S. Hohman, Bruna Araújo David, Paul Kubes, Matthias Mack, Ehud Inbar, Nathan C. Peters
The paper shows that pre-existing Th1 immunity is overcome by monocyte-derived macrophages that create a pathogen niche, and that checkpoint blockade or depletion of these cells improves parasite control.
bioRxiv · Aug 19, 2026 · PreprintImmunology