Author

Santiago Aguiar Espellet Soares

University of CalgaryORCID 0000-0001-9063-9294Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Ben Perks· 1 shared Bruna Araújo DavidiD· 1 shared Camila Gaio· 1 shared Chris TiesseniD· 1 shared Ehud Inbar· 1 shared Leah S. HohmaniD· 1 shared Matheus Batista Heitor CarneiroiD· 1 shared Matthias MackiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Ben Perks

Mutual co-authors in cluster

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1 paper

Recent·Most cited

Pre-existing Th1 immunity is abrogated by ongoing recruitment of monocytic host cells that are refractory to activation

Matheus Batista Heitor Carneiro, Santiago Aguiar Espellet Soares, Chris Tiessen, Camila Gaio, Ben Perks, Leah S. Hohman, Bruna Araújo David, Paul Kubes, Matthias Mack, Ehud Inbar, Nathan C. Peters

The paper shows that pre-existing Th1 immunity is overcome by monocyte-derived macrophages that create a pathogen niche, and that checkpoint blockade or depletion of these cells improves parasite control.

bioRxiv · Aug 19, 2026 · PreprintImmunology