Nathan C. Peters

Pre-existing Th1 immunity is abrogated by ongoing recruitment of monocytic host cells that are refractory to activation

The paper shows that pre-existing Th1 immunity is overcome by monocyte-derived macrophages that create a pathogen niche, and that checkpoint blockade or depletion of these cells improves parasite control.

The pore-forming protein APOL7C ruptures Leishmania major-containing parasitophorous vacuoles in dendritic cells to promote IL-12 production and the induction of T helper type 1 immunity

Dysregulated lymphatic remodeling promotes immunopathology during non-healing cutaneous leishmaniasis

This study shows impaired lymphatic function contributes to non-healing cutaneous leishmaniasis caused by L. amazonensis and demonstrates that targeting lymphatics can reduce inflammation.