Olga Ilkayeva

SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice

This study identifies SIRT4 as a lysine deitaconylase that regulates macrophage inflammatory responses and wound healing by modulating protein itaconylation in mice.

Pathway Coessentiality Mapping Reveals Complex II is Required for de novo Purine Biosynthesis in Acute Myeloid Leukemia

The paper identifies Complex II's role in de novo purine biosynthesis in AML using CRISPR and metabolomic data, showing it as a therapeutic target.

Integration of metabolomic and transcriptomic analyses reveals novel regulatory functions of the ChREBP transcription factor in energy metabolism

This study integrates transcriptomic and metabolomic analyses to reveal novel regulatory functions of ChREBP in mitochondrial metabolism and cellular energy balance beyond its canonical roles in carbohydrate and lipid metabolism.

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

This study examines how endurance exercise training affects rat subcutaneous white adipose tissue, revealing sex-specific molecular responses and differences in adiposity and metabolism.

Temporal dynamics of the multi-omic response to endurance exercise training across tissues

This study profiles multi-omic changes in multiple tissues of rats during endurance exercise training, identifying molecular adaptations and sex-specific responses across time.

De novo lipogenesis fuels adipocyte autophagosome membrane dynamics

This study identifies de novo lipogenesis as a critical source of fatty acids for autophagosome membrane dynamics in adipocytes, showing that Fasn deficiency impairs autophagy and p62 degradation.

Paradoxical activation of SREBP1c and de novo lipogenesis by hepatocyte-selective ACLY depletion in obese mice.

The paper shows that ACLY depletion in obese mice paradoxically increases de novo lipogenesis despite reducing AcCoA levels, linked to increased SREBP1c expression.

Super-enhancer signature reveals key mechanisms associated with resistance to non-alcoholicsteatohepatitis in humans with obesity

The paper identifies distinct enhancer signatures in NASH-prone and NASH-resistant human obesity patients, revealing key genes and pathways associated with resistance.

Type-2-diabetes alters CSF but not plasma metabolomic and AD risk profiles in vervet monkeys

This study shows that type 2 diabetes in vervet monkeys alters cerebrospinal fluid metabolites and amyloid levels, but not plasma metabolites or AD risk profiles.

Multi-Omic Profiling Reveals the Opposing Forces of Excess Dietary Sugar and Fat on Liver Mitochondria Protein Acetylation and Succinylation

The paper investigates how excess dietary sugar and fat affect liver mitochondria protein acetylation and succinylation in mice through multi-omic profiling.