John Bradley

datadrivenhypothesis.org integrates gene and pathway data to uncover metabolic connections and generate hypotheses about gene function.

The paper develops DRUG-seq to profile drug responses in primary human cells, revealing shared and cell-type-specific transcriptional changes across multiple compounds and concentrations.

The paper identifies Complex II's role in de novo purine biosynthesis in AML using CRISPR and metabolomic data, showing it as a therapeutic target.

The paper identifies intrinsic DNA-binding specificity differences between transcription factor paralogs that partly explain their distinct genomic binding patterns.