Structural and functional basis of PU.1-BAF interaction enables targeting of lineage-specific transcription
Dipti Sadalge, Jozlyn R. Clasman, Salih Topal, Derek M. Musser, Laura Von der Porten, Siying Wu, Samantha E. Schultz, Wesley Austin, David C.S. Huang, Ying‐Duo Gao, Jeremy W. Setser, Marissa R. Martinez, Janna Kiselar, Stephen Hesler, Sydney J. Blevins, , Asad M. Taherbhoy
This paper identifies the structural basis of PU.1-BAF interaction and shows small molecules can disrupt it, offering a new therapeutic strategy for cancer.
bioRxiv · Aug 1, 2025 · PreprintMolecular Biology