Roberto Domínguez

The paper shows tropomodulin and leiomodin nucleate tropomyosin clusters on actin filaments, with tropomodulin acting at the pointed end and leiomodin along the entire filament.

This study shows that loss of Leiomodin1 in vascular smooth muscle cells causes rapid coronary atherosclerosis in mice, independent of actin nucleation, and highlights Thbs1 as a target for mitigating foam cell formation.

This study investigates how gelsolin severs and caps actin filaments through structural analysis of its interactions with F-actin.

This study shows myosin-I enhances the force generation of Arp2/3 complex-nucleated actin networks by thinning them and promoting symmetry breaking.

This study shows that Drosophila Tropomodulin is essential for actin-dependent processes in myofiber assembly and maintenance, leading to myopathy-related phenotypes when disrupted.

This study reveals structural insights into the RSC chromatin remodeling complex by showing how ARP binding induces conformational changes and enhances nucleosome remodeling.