Author

Jeremy W. Setser

Foghorn Therapeutics (United States)ORCID 0000-0002-2032-6740Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexis Khalil· 1 shared Asad M. TaherbhoyiD· 1 shared Bengi Turegun· 1 shared Bradley M. DicksoniD· 1 shared Claudia M. CremersiD· 1 shared Daniele PeterleiD· 1 shared David C.S. HuangiD· 1 shared David L. Lahr· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Alexis Khalil

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2 papers

Recent·Most cited

Thermodynamic Insights into the WT and Y220C TP53 DBDs Reveals that the Oncogenic Y220C Variant is a Loss of Function Mutation for Zn2+-binding at Physiological Temperature

Jacob I. Stuckey, Valérie Vivat, Bradley M. Dickson, Jeremy W. Setser, Yong Li, Claudia M. Cremers, Jonathan E. Wilson, Daniele Peterle, John R. Engen, Thomas E. Wales, Rainer Wilcken, Erin B. Rohan, Gregg Chenail, James E. Audia, Robert J. Sims

The paper investigates the thermodynamic effects of the Y220C TP53 mutation on Zn2+-binding and shows that Rezatapopt restores Zn2+-affinity through two pathways.

Biochemistry · Sep 1, 2026Peer-reviewedBiochemistry

Structural and functional basis of PU.1-BAF interaction enables targeting of lineage-specific transcription

Dipti Sadalge, Jozlyn R. Clasman, Salih Topal, Derek M. Musser, Laura Von der Porten, Siying Wu, Samantha E. Schultz, Wesley Austin, David C.S. Huang, Ying‐Duo Gao, Jeremy W. Setser, Marissa R. Martinez, Janna Kiselar, Stephen Hesler, Sydney J. Blevins, , Asad M. Taherbhoy

This paper identifies the structural basis of PU.1-BAF interaction and shows small molecules can disrupt it, offering a new therapeutic strategy for cancer.

bioRxiv · Aug 1, 2025 · PreprintMolecular Biology