Cancer associated fibroblasts drive epithelial to mesenchymal transition and classical to basal change in pancreatic ductal adenocarcinoma cells with loss of IL-8 expression
Samantha R. Guinn, Brayan Perez, Joseph A. Tandurella, Mili Ramani, Jae Woo Lee, Daniel J. Zabransky, Emma Kartalia, Jignasha G. Patel, Haley Zlomke, Norman G. Nicolson, Sarah M. Shin, Benjamin Barrett, Nicholas Sun, Alexei Hernandez, Erin M. Coyne, , Jacquelyn W. Zimmerman
The paper investigates how cancer-associated fibroblasts (CAF) influence tumor cell behavior in pancreatic ductal adenocarcinoma by driving EMT and altering cell subtypes, with IL-8 playing a key modulatory role.
bioRxiv · Jan 7, 2025 · PreprintCancer Biology