A single residue determines regulation of TRPV1 by phosphoinositides
Benjamin He, Prateeti Varanasi, Nia M Barkum, Rose Hudson, Eric N. Senning
This paper identifies a single residue, H410, that determines how TRPV1 interacts with phosphoinositides, revealing a two-site binding mechanism for PI(4,5)P2 regulation.
bioRxiv · Oct 15, 2025 · PreprintBiophysics