Eric N. Senning

A single residue determines regulation of TRPV1 by phosphoinositides

This paper identifies a single residue, H410, that determines how TRPV1 interacts with phosphoinositides, revealing a two-site binding mechanism for PI(4,5)P2 regulation.

Missense variant analysis in the TRPV1 ARD reveals the unexpected functional significance of a methionine

The paper identifies M308 in TRPV1's ARD as a functionally significant residue with implications for channel activity and splice variant expression.

Fluorescence labeling strategies for the study of ion channel and receptor cell surface expression: A comprehensive toolkit for extracellular labeling of TRPV1.

This paper develops two orthogonal strategies to label TRPV1 on the cell surface with minimal functional perturbation, enabling tracking of its expression and mobility.