DNA2 and FANCM function in two distinctive pathways in disrupting TERRA R-loops and suppressing replication stress at ALT telomeres
Ashwin Ragupathi, Heba Zuhair Abid, Yun Chen, Rongwei Zhao, Settapong T Kosiyatrakul, Derin I. Yetil, Julia Neiswander, Rachel Feltman, Shannon Thomas, Benjamin Yusupov, Manrose Singh, Zheng Li, Binghui Shen, Huaiying Zhang, Hsueh-Ping C. Chu, , Dong Zhang
This study shows DNA2 and FANCM function in distinct pathways to suppress replication stress at ALT telomeres, with their combined depletion causing synthetic lethality in ALT+ cancers.
bioRxiv · May 22, 2025 · PreprintCancer Biology