Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle
Mariana Conceição, Laura Forcina, Oscar P. B. Wiklander, Dhanu Gupta, Joel Z. Nordin, Besarte Vrellaku, Graham McClorey, Imre Mäger, André Görgens, Per Lundin, Antonio Musarò, Matthew J. A. Wood, Samir EL Andaloussi, Thomas C. Roberts
This study engineers extracellular vesicles with IL6ST decoy receptors to inhibit the IL6 trans-signalling pathway, showing efficacy in vitro and in a Duchenne muscular dystrophy mouse model.
Biomaterials · Oct 5, 2020Peer-reviewedMolecular Biology