Imre Mäger

This study develops an engineered extracellular vesicle platform that improves shRNA loading and delivery efficiency, achieving robust gene silencing in multiple cell types and the mouse brain.

This study shows that RNAx, a leader-protein-encoding mRNA, reduces reactogenicity while maintaining immunogenicity in saRNA-LNP vaccines.

This paper develops a PTTG1IP-based platform for efficient extracellular vesicle (EV) cargo delivery, showing improved therapeutic delivery compared to CD63-based scaffolds.

This study shows GAPDH facilitates EV biogenesis and enables efficient siRNA delivery to the brain, reducing huntingtin gene expression in a mouse model.

The paper shows that most extracellular miRNAs are secreted non-vesicularly, with only <2% associated with EVs, even though EVs can stabilize miRNAs in serum.

This study engineers extracellular vesicles with IL6ST decoy receptors to inhibit the IL6 trans-signalling pathway, showing efficacy in vitro and in a Duchenne muscular dystrophy mouse model.