Focused Ultrasound Thermal Ablation and CD40 Agonism Reprograms Breast Tumor Immunity to Drive Regression and Memory
Zehra E.F. Demir, AeRyon Kim, Beyzanur G Ak, Micaiah SJ Lee, Thomas Sherlock, Stefanyda Maslova, Andrew T Thede, Pouria Talebibarmi, Matthew R. DeWitt, Melanie R. Rutkowski, Natasha Sheybani
This study shows that combining focused ultrasound thermal ablation with CD40 agonism enhances tumor immunity, leading to durable regression and immunological memory in breast cancer models.
Journal for ImmunoTherapy of Cancer · Aug 1, 2026Peer-reviewedCancer Biology