NeurosciencebioRxivPreprint
IsoDGR-Induced Endothelial Cytoskeletal Disruption Drives Age-Related Blood-Brain Barrier Breakdown
Ridhi Patel, Pazhanichamy Kalailingam, SoFong Cam Ngan…·Siu Kwan Sze
This study identifies isoDGR-induced endothelial cytoskeletal disruption as a key driver of age-related BBB breakdown and shows that targeting isoDGR preserves BBB integrity and reduces neuroinflammation.
DOI 10.1101/2025.07.08.663800