Dominique P.V. de Kleijn

This study identifies shared genetic risk between major depression and atherosclerotic diseases and links causal gene expression changes in blood, brain, and heart tissues to depression etiology.

The paper integrates multi-modal omics data to identify therapeutic pathways in atherosclerosis for coronary heart disease, highlighting amino acid metabolism and 16 relevant proteins.

This study identifies isoDGR-induced endothelial cytoskeletal disruption as a key driver of age-related BBB breakdown and shows that targeting isoDGR preserves BBB integrity and reduces neuroinflammation.

This study shows that an anti-isoDGR antibody reduces atherosclerosis and metabolic dysfunction in ApoE-/- mice fed a Western diet.

The paper identifies gene signatures of endothelial-to-mesenchymal transition in human atherosclerotic tissue using combined in vitro and single-cell transcriptomic data.

This study investigates the association between kynurenine and NAD+ pathway metabolites and macrophage content and polarization in carotid plaques, finding higher kynurenine levels correlate with M1 macrophages and reduced NAD+.

The paper identifies female-biased VSMC gene regulatory networks and highlights MYH9 as a key regulator of fibrous plaque phenotype in females.

The paper identifies sex-stratified gene regulatory networks in atherosclerotic plaques, showing female plaques are enriched with myofibroblast-like smooth muscle cell networks.

This study examines the association between family history and polygenic risk scores with secondary cardiovascular events in patients undergoing carotid endarterectomy, finding both factors independently increase risk.

The paper investigates the association between genetic risk variants and clinical features of abdominal aortic aneurysms using a biobank cohort, finding a weak polygenic correlation with aneurysm diameter but no clear individual variant associations.