Pazhanichamy Kalailingam

This study shows that inducing oxidative stress in pancreatic cancer cells creates an effective whole-cell vaccine that enhances anti-tumor immunity and synergizes with PD-1 blockade.

This study shows that smooth muscle dysfunction caused by ACTA2 mutations leads to cerebrovascular reserve failure, increasing brain vulnerability to hypoperfusion and injury.

This paper develops a customized CRISPR-Cas9 base editor to correct the ACTA2 R179H mutation in a mouse model of MSMDS, improving survival and rescuing vascular and neurological phenotypes.

This study identifies isoDGR-induced endothelial cytoskeletal disruption as a key driver of age-related BBB breakdown and shows that targeting isoDGR preserves BBB integrity and reduces neuroinflammation.

This study shows that an anti-isoDGR antibody reduces atherosclerosis and metabolic dysfunction in ApoE-/- mice fed a Western diet.

This study shows that Mfsd2b and Spns2 are essential for embryonic vascular development and vascular homeostasis, and their loss leads to severe hemorrhage and anaphylaxis susceptibility.