IsoDGR-Induced Endothelial Cytoskeletal Disruption Drives Age-Related Blood-Brain Barrier Breakdown
Ridhi Patel, Pazhanichamy Kalailingam, SoFong Cam Ngan, Ranjith Iyappan, Jones Nwaeze, Bianca D’Amore, Maryam Katoueezadeh, Yazhini Thinakaran, Mahdi Hejazi Laein, Brent E. Faught, Rebecca E. K. MacPherson, Evangelia Tsiani, Panagiota Klentrou, Dominique P.V. de Kleijn, Raj N. Kalaria, , Siu Kwan Sze
This study identifies isoDGR-induced endothelial cytoskeletal disruption as a key driver of age-related BBB breakdown and shows that targeting isoDGR preserves BBB integrity and reduces neuroinflammation.
bioRxiv · Jul 8, 2025 · PreprintNeuroscience