Oxidative Stress-Induced Immunogenic Cell Death Enhances Whole-Cell Vaccine Efficacy in a Syngeneic Pancreatic Cancer Model
Maryam Katoueezadeh, Yazhini Thinakaran, Mahdi Hejazi Laein, Ranjith Iyappan, SoFong Cam Ngan, Jake Baker, Ridhi Patel, Pazhanichamy Kalailingam, Rebecca E. K. MacPherson, Panagiota Klentrou, Evangelia Tsiani, Jee Keem Low, Neil E. McCarthy, Siu Kwan Sze
This study shows that inducing oxidative stress in pancreatic cancer cells creates an effective whole-cell vaccine that enhances anti-tumor immunity and synergizes with PD-1 blockade.
bioRxiv · Feb 11, 2026 · PreprintCancer Biology