Induction of TFEB promotes Kupffer cell survival and reduces lipid accumulation and inflammation in MASLD
Mandy M. Chan, Sabine Daemen, Wandy L. Beatty, Kathleen Byrnes, Kevin Cho, Daniel Ferguson, Arick C. Park, Christina F. Fu, Zhen Guo, Natalie Feldstein, Christopher Park, Kira L. Florczak, Li He, Bin Q Yang, Ali Javaheri, , Joel D. Schilling
This study shows that inducing TFEB in Kupffer cells reduces cell death, lipid accumulation, and inflammation in MASLD.
bioRxiv · Apr 19, 2025 · PreprintImmunology