Wandy L. Beatty

This study encapsulates AAVs into protein vault nanoparticles to bypass neutralizing antibodies, enabling effective gene therapy despite preexisting immunity.

The paper identifies distinct transcriptional and epigenetic profiles of brain-engrafted monocyte-derived macrophages compared to microglia, showing their origin from peripheral blood and skull bone marrow.

This study investigates the role of Dma2 in OMV biogenesis and colonization fitness in Bacteroides thetaiotaomicron, showing that dma2 mutation increases OMV production and affects polysaccharide utilization loci expression, leading to reduced colonization fitness.

This study investigates the role of alternative oxidase (AOX) and type II NADH dehydrogenase (NDH2) in generating the mitosome membrane potential in Cryptosporidium parvum, finding both genes are non-essential and not the target of known inhibitors.

This study identifies the signal peptidase complex (SPC) as essential for rotavirus VP7 processing and virion assembly, showing that SPC cleavage of VP7's signal peptide is critical for infectious particle formation.

This paper introduces RAPPL, a rapid, simple, and cost-effective method for isolating ribosomes and translational machinery, demonstrating its utility in functional and structural studies across various species and sample types.

This study shows that inducing TFEB in Kupffer cells reduces cell death, lipid accumulation, and inflammation in MASLD.

This study shows that Stathmin 1 regulates mitophagy and mitochondrial health in hematopoietic stem cells by maintaining microtubule architecture and autophagy processes.

This study identifies SLC35A2 as a host factor essential for paramyxovirus fusion during infection, showing its role in virus-cell and cell-to-cell fusion events.

The paper shows that host-derived CEACAM-laden vesicles capture ETEC and its toxins, reducing pathogen load and neutralizing toxins during infection.

This paper introduces a novel gene therapy platform using covalently linked adenovirus-AAV complexes to improve co-infection efficiency and reduce AAV dose requirements.

This paper develops an inducible genetic tool to study microglial states in development and disease, revealing their plasticity and functional roles.