AMPKγ2 Deacetylation Drives Nuclear Translocation and Doxorubicin-Induced Cardiomyopathy via Nucleolar Stress Signaling
Canrong Li, Tiantian Yi, Y M Cui, Baicheng Cheng, Juan Lan, C H I Zhang, Cha Lin, F Y Yang, Ye Chen, X Wang, Hong Peng, Bin Zhao, Leping Yan, Hor‐Yue Tan, Xiaoduo Xie
This study identifies AMPKγ2 deacetylation as a driver of Doxorubicin-induced cardiomyopathy through nucleolar stress and p53-mediated apoptosis, suggesting HDAC inhibitors could mitigate cardiac toxicity.
bioRxiv · Jul 16, 2026 · PreprintCell Biology