Jinhong Yan

Physics-informed self-supervised learning enables spectra-free multiplexed imaging on standard fluorescence microscopes

This paper introduces PhySMI, a self-supervised framework for multiplexed imaging without spectral measurements, achieving high multiplexing with reduced crosstalk and improved imaging performance.

Light-sheet excitation-encoded volumetric spectroscopy for fast multiplexed imaging and quantitative physicochemical mapping in cells

This paper introduces LS-ExSM, a method for fast multiplexed imaging and quantitative physicochemical mapping in cells, demonstrating six-color volumetric imaging and lipid-droplet polarity mapping.

High-throughput, unbiased single-molecule displacement mapping with deep learning reveals spatiotemporal heterogeneities in intracellular diffusivity

This paper introduces Hi-SMdM, a high-throughput single-molecule diffusivity microscopy approach that enables unbiased mapping of spatiotemporal heterogeneities in intracellular diffusivity with improved resolution and throughput.

Excitation Spectral Phasor Microscopy (ExSPM) unveils spatiotemporal heterogeneities in polarity of intracellular lipid droplets

ExSPM reveals spatiotemporal heterogeneities in lipid droplet polarity, showing dynamics and pathway-specific kinetics of lipid metabolism.