C H I Zhang

RNAStabFormer predicts RNA stability from pulse-chase transcriptomics using a hybrid transformer model, achieving performance comparable to tabular baselines.

This study identifies AMPKγ2 deacetylation as a driver of Doxorubicin-induced cardiomyopathy through nucleolar stress and p53-mediated apoptosis, suggesting HDAC inhibitors could mitigate cardiac toxicity.

OCellus is a language model that addresses limitations in single-cell, spatial, and perturbation biology by integrating natural-language reasoning across multiple tasks.

The paper identifies and characterizes UGT76 glycosyltransferases in Codonopsis pilosula that catalyze the biosynthesis of polyacetylene glycosides, revealing a novel tunnel-based substrate recognition mechanism.

The paper benchmarks structure prediction models for scFv-Ag complexes using a large-scale dataset and evaluates confidence metrics for selecting high-quality predictions.

This paper introduces AMPHORA, a pathogen-conditioned generator of antimicrobial peptides, showing that incorporating pathogen-specific features improves peptide design and potency.

The paper constructs a developmental cell atlas of the human esophagus and develops in vitro models that recapitulate esophageal architecture, revealing WNT2B's role in regulating basal progenitor self-renewal.

The paper reveals deterministic microbial succession in coastal oceans driven by active non-redundancy and viral orchestration, using metatranscriptomic data from Daya Bay.

This study identifies a horizontally transferred fungal deubiquitinase, BtUCH19, that enhances insecticide resistance in whiteflies by stabilizing a detoxification enzyme through ubiquitin modification.