CTCF mediated genome architecture regulates the dosage of mitotically stable mono-allelic expression of autosomal genes
Keerthivasan Raanin Chandradoss, Bindia Chawla, Shivnarayan Dhuppar, Rakhee Nayak, Rajesh Ramachandran, Sreenivasulu Kurukuti, Aprotim Mazumder, Kuljeet Singh Sandhu
The paper shows that CTCF-mediated chromatin loops create genomic insulation that enables mono-allelic expression of autosomal genes and protects their dosage from fluctuations.
Cell Reports · Oct 1, 2020Peer-reviewedGenomics