Kuljeet Singh Sandhu

This study identifies evolutionary changes in protein disorder in naked mole rats that contribute to their unique physiological traits.

The paper identifies conserved noncoding elements lost in cavefish that contribute to regressed phenotypes by disrupting developmental pathways.

This study identifies that left-handed glycyl conformations protect against protein aggregation and enhance stability by disrupting beta-strand pairing.

The paper shows Swi6/HP1 binds siRNA-DNA hybrids at dg-dh repeats to initiate heterochromatin formation independently of H3-K9 methylation.

The paper shows that CTCF-mediated chromatin loops create genomic insulation that enables mono-allelic expression of autosomal genes and protects their dosage from fluctuations.

The paper identifies the PAF1 complex as a regulator of RNA polymerase III transcription, showing it restricts pol III accumulation and reduces replication stress on transcribed genes.

The paper shows HiC datasets have bias due to chromatin condensation, which can be used to study dynamic chromatin states.

The paper examines how loss of synteny between genes and conserved noncoding elements (CNEs) impacts developmental gene expression in rodents, linking it to evolutionary changes in brain development.