Aprotim Mazumder

Ligand-dependent Enhancer Activation Indirectly Modulates Non-target Promoters in a Chromatin Domain

The paper shows that enhancer activation during estrogen signaling indirectly represses neighboring non-target genes within the same TAD through dynamic chromatin interactions.

Nucleolar reorganization on stress depends on physicochemical changes due to nascent rRNA synthesis

This study shows that nucleolar reorganization under stress is driven by changes in nascent rRNA synthesis, not signaling pathways.

HP1α-driven Phase Separation and Repair Pathway Choice in Response to Heterochromatin Damage

This study shows HP1 and HP1β promote differential recruitment of HR and NHEJ factors at DSBs, with HP1 phase separation essential for HR recruitment.

Mechanics-dependent Global Nuclear Eviction and Site-Specific Recruitment of YAP Regulates DNA Damage Responses

This study shows YAP translocates in response to DNA damage, enhancing DDR signaling globally and recruiting repair proteins locally.

Buffered EGFR signaling regulated by spitz to argos expression ratio is critical for patterning the Drosophila eye

The paper shows that the ratio of spitz to argos expression, not absolute levels, determines Drosophila eye patterning through buffered EGFR signaling.

CTCF mediated genome architecture regulates the dosage of mitotically stable mono-allelic expression of autosomal genes

The paper shows that CTCF-mediated chromatin loops create genomic insulation that enables mono-allelic expression of autosomal genes and protects their dosage from fluctuations.