Methionine regulates antitumor function of CD8⁺ T cells through polyamine synthesis
Tian Zhao, Gillian A. Carleton, Sarah MacPherson, Madison Shiyuk, Joseph Monaghan, Jun Han, Oro Uchenunu, Robert K. Rottapel, Ralph J. DeBerardinis, Kelly M. Stewart, Bo-Hyun Kim, Juan Ausió, David R. Goodlett, Helena Pětrošová, Kyle D. Duncan, Julian J. Lum
This study shows that methionine restriction affects CD8+ T cell function through polyamine synthesis, but does not improve antitumor efficacy in vivo.
bioRxiv · Oct 3, 2025 · PreprintImmunology