Deletion of LRP1 in Smooth Muscle Cells Induces Infrarenal Aortic Aneurysms in Mice
Michael Franklin, Guan Fan, Bowen Li, Pengjun Wang, Deborah A. Howatt, Jessica J. Moorleghen, Adam E. Mullick, Alan Daugherty, Hong S. Lu
This study shows that deleting LRP1 in smooth muscle cells causes infrarenal aortic aneurysms in mice, which can be mitigated by inhibiting hepatocyte-derived angiotensinogen.
bioRxiv · Oct 22, 2026 · PreprintPathology