Author

Lin Zhang

Wenzhou Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Immunology· 2 Bioinformatics· 1 Cancer Biology· 1 Developmental Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 6 Organism:human· 6 Approach:statistical model· 6 Assay:bulk RNA-seq· 4 Research Focus:gene regulatory network inference· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:proteomics· 3

Frequent Co-Authors

Ming Chen· 2 shared Pengxia Song· 2 shared Qianru Xu· 2 shared Sijie Zhan· 2 shared Xiaobo Liu· 2 shared Xingchen ZhouiD· 2 shared Yubin LiuiD· 2 shared Zhen Le· 2 shared

Activity by Year

2022-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Ming Chen

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

An Oxidative Stress-Associated Seven-Gene Prognostic Signature in Lung Adenocarcinoma: Integrative Transcriptomic Analysis Across Public Cohorts

Xingchen Zhou, Zhen Le, Pengxia Song, Qianru Xu, Ming Chen, Xiaobo Liu, Sijie Zhan, Yubin Liu, Lin Zhang

This study identifies a seven-gene oxidative stress signature in lung adenocarcinoma that stratifies patients by survival, validated across multiple cohorts with moderate prognostic accuracy.

bioRxiv · Sep 15, 2026 · PreprintCancer Biology

An inflammation-associated five-gene expression signature stratifies survival and immune states in lung adenocarcinoma: an integrative public-cohort analysis

Xingchen Zhou, Zhen Le, Pengxia Song, Qianru Xu, Ming Chen, Xiaobo Liu, Mengnan Cao, Sijie Zhan, Yubin Liu, Lin Zhang

The paper identifies a five-gene expression signature associated with inflammation that stratifies survival and immune states in lung adenocarcinoma across multiple cohorts.

bioRxiv · Aug 25, 2026 · PreprintBioinformatics

Epigenetic Programming of Macrophage Phenotypes by STING-IRF3 Drives Inflammation in Ascending Thoracic Aortic Dissection

Bowen Li, Chen Zhang, Samantha Xu, Yanming Li, Deborah C. Vela, Hernan G. Vasquez, Lin Zhang, Abhijit Chakraborty, Hong S. Lu, Joseph S. Coselli, Toru Suzuki, Alan Daugherty, Dianna M. Milewicz, Ziad Mallat, Liwu Li, , Ying H. Shen

This study identifies STING-IRF3-mediated epigenetic programming of macrophages as a driver of inflammation in aortic dissection, showing its role in pro-inflammatory bias and therapeutic potential.

bioRxiv · Jan 25, 2026 · PreprintImmunology

Ethylene signal-driven plant-multitrophic synergy boosts crop performance

Marcel Baer, Yanting Zhong, Baogang Yu, Tian Tian, Xiaoming He, Ling Gu, Xiaofang Huang, Elena Gallina, Isabelle Elisabeth Metzen, Marcel Bucher, Rentao Song, Caroline Gutjahr, Zhen Su, Yudelsy A.T. Moya, Nicolaus von Wirén, , Peng Yu

This study identifies ERF transcription factors as key regulators of AM fungal-induced lateral root development in maize, revealing a tripartite signaling network involving ethylene, flavonoids, and microbial synergies.

bioRxiv · Nov 28, 2025 · PreprintPlant Biology

Maternal IBD-related antibodies are associated with early life gut inflammatory status and microbiota composition: insights from cord blood

Taegyu Kim, Paola Nicoletti, María Manuela Estevinho, Leonid Tarassishin, Mellissa Picker, Anketse Debebe, Isabella Nguyen, Rhiannon Dutra-Clarke, Courtney Young, James L. Stone, Ariella Bar‐Gil Shitrit, Manasi Agrawal, Jean–Frédéric Colombel, Joana Torres, Siew C. Ng, , Inga Peter

The paper examines maternal IBD-related antibodies in cord blood and their associations with early life gut inflammation and microbiota composition.

bioRxiv · Aug 4, 2025 · PreprintImmunology

Gastrula-premarked posterior enhancer primes posterior tissue development through cross-talk with TGF-β signaling pathway

Yingying Chen, Fengxiang Tan, Qing Fang, Lin Zhang, Jiaoyang Liao, Penglei Shen, Yun Qian, Mingzhu Wen, Rui Song, Yonggao Fu, He Jax Xu, Ran Wang, Cheng Li, Zhen Shao, Jinsong Li, , Xianfa Yang

The paper identifies a pre-marked enhancer, p-Enh, that primes posterior tissue development in mouse embryos through interaction with the TGF-β signaling pathway.

Advanced Science · Jun 29, 2025Peer-reviewedDevelopmental Biology

Genome folding principles revealed in condensin-depleted mitotic chromosomes

Han Zhao, Yinzhi Lin, En Lin, Fuhai Liu, Lirong Shu, Dannan Jing, Baiyue Wang, Manzhu Wang, Fengnian Shan, Lin Zhang, Jessica C. Lam, Susannah C. Midla, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, , Haoyue Zhang

This study investigates genome folding in condensin-depleted mitotic chromosomes, revealing compartmentalization mechanisms distinct from interphase.

bioRxiv · Nov 9, 2023 · PreprintGenomics

Elevated ENO2 Disrupts VSMCs Homeostasis Facilitating the Development of Aortic Dissection

Weixing Cai, Li Zhang, Jingjing Lin, Qiuying Zou, Chaoyun Wang, Xi Yang, Xiaohui Wu, Jianqiang Ye, Hui Wen Zheng, Lin Zhang, Lin Zhong, Xinyao Li, Keyuan Chen, Jiangbin Wu, Liangwan Chen, Yumei Li

This study shows that elevated ENO2 disrupts autophagy in vascular smooth muscle cells, contributing to aortic dissection development.

bioRxiv · Mar 23, 2023 · PreprintMolecular Biology

Stress-associated purinergic receptors code for fatal suicidality in the hippocampal-hypothalamic-prefrontal circuit

Lin Zhang, Ronald W. H. Verwer, Joop J. van Heerikhuize, Rawien A. Balesar, Felipe Corrêa‐da‐Silva, Zala Slabe, Paul John Lucassen, Dick Frans Swaab

The paper identifies purinergic receptor expression patterns in specific brain regions associated with fatal suicidality in individuals with mood disorders.

bioRxiv · Nov 22, 2022 · PreprintNeuroscience