Yanming Li

Metabolic control of smooth muscle cell phenotype switching in atherosclerosis

This study identifies PDK4 as a regulator of TGF{beta}-mediated SMC contractility, showing that reducing PDK4 limits atherosclerosis by preserving SMC phenotype.

Epigenetic Programming of Macrophage Phenotypes by STING-IRF3 Drives Inflammation in Ascending Thoracic Aortic Dissection

This study identifies STING-IRF3-mediated epigenetic programming of macrophages as a driver of inflammation in aortic dissection, showing its role in pro-inflammatory bias and therapeutic potential.

Smooth Muscle Cells and Fibroblasts in the Proximal Thoracic Aorta Exhibit Minor Differences Between Embryonic Origins in Angiotensin II-driven Transcriptional Alterations

The paper examines transcriptomic changes in smooth muscle cells and fibroblasts from different embryonic origins in the proximal thoracic aorta under AngII infusion, finding modest differences between origins.

Transcriptomic Gene Network Profiling and Weak Signal Detection for Prediction of Ovarian Cancer Occurrence, Survival, and Severity by Integrating Bulk and Single-cell RNAseq Data

The paper integrates bulk and single-cell RNAseq data to identify predictive gene networks and weak genes for ovarian cancer occurrence, survival, and clinical stage using netLDA, improving prediction performance.

Mapping Human Pluripotent Stem Cell Derived Erythroid Differentiation by Single-Cell Transcriptome Analysis

This study maps the differentiation trajectory of iPSC-derived erythroid cells using single-cell transcriptomics, identifying key transcription factors and cell types.

Exome-by-phenome-wide rare variant gene burden association with electronic health record phenotypes

This study identifies robust gene-phenotype associations by analyzing rare loss-of-function variants in exome-wide data linked to electronic health records.