Michael Franklin

This study shows that PAI-1 deficiency leads to early cardiac hemorrhage and fibrosis under hemodynamic stress, with mutations in the protease-inhibitory domain causing similar pathology.

This study shows that deleting LRP1 in smooth muscle cells causes infrarenal aortic aneurysms in mice, which can be mitigated by inhibiting hepatocyte-derived angiotensinogen.

This study shows that Angiotensin II exacerbates mitral valve and left atrial pathology in Fbn1C1041G/+ mice, while AGT inhibition does not alter the phenotype.

This study shows that deleting angiotensinogen in hepatocytes protects mice from diet-induced metabolic disorders even under thermoneutral conditions that mimic human metabolism.

This study shows that AngII infusion worsens aortic pathology in Fbn1C1041G/+ mice, leading to aortic rupture and branch aneurysms.

This study investigates whether metformin reduces AngII-induced aortic aneurysms in LDLR-/- mice and finds it does not.

This study shows that cilostazol and sildenafil do not prevent BAPN-induced thoracic aortopathy in mice.

This study shows that deleting megalin in renal proximal tubule cells does not reduce atherosclerosis but causes tubulointerstitial nephritis in male mice fed a Western diet.

This study shows that renal angiotensinogen in nonhuman primates is mainly derived from the liver, as evidenced by reduced renal AGT levels after liver-specific AGT inhibition.