Transfer RNA Genes Affect Chromosome Structure and Function via Local Effects
Omar Hamdani, Namrita Dhillon, Tsung-Han S. Hsieh, Takahiro Fujita, Josefina Ocampo, Jacob G. Kirkland, Josh Lawrimore, Tetsuya J. Kobayashi, Brandon Friedman, Derek Fulton, Kenneth Y. Wu, Răzvan V. Chereji, Masaya Oki, Kerry Bloom, David J Clark, , Rohinton T. Kamakaka
This study shows that removing tRNA genes from a chromosome does not broadly disrupt chromosome folding but affects local nucleosome positioning and SMC protein binding, as well as centromere and heterochromatin clustering.
Molecular and Cellular Biology · Feb 4, 2019Peer-reviewedMolecular Biology