Jacob G. Kirkland

The paper shows that cell identity and regulatory logic are preserved during brain aging, but cell-type-specific changes occur in DNA modifications and gene expression.

This study identifies cBAF as a regulator of AR-V7 expression through chromatin-mediated transcriptional termination in CRPC.

This study investigates cohesin dynamics during mouse embryonic stem cell differentiation, finding that regulators like WAPL and ESCO1, not cohesin abundance, drive changes in cohesin behavior.

The paper shows that cBAF complexes, but not gBAF or pBAF, remove polycomb repressive histone marks from the Nkx2.9 locus in mESCs, leading to transcriptional activation.

This study shows that the BAF complex both antagonizes and promotes polycomb-mediated repression by redistributing polycomb complexes across the genome in embryonic stem cells.

This study shows that removing tRNA genes from a chromosome does not broadly disrupt chromosome folding but affects local nucleosome positioning and SMC protein binding, as well as centromere and heterochromatin clustering.