Josefina Ocampo

H3K4me3 exhibits length-dependent deposition patterns at transcription initiation regions in Trypanosoma cruzi and correlates with transcriptional activity

The paper maps H3K4me3 in T. cruzi and finds it correlates with transcriptional activity and genomic span of initiation regions.

Beyond the transcript: chromatin implications in trans-splicing in Trypanosomatids

The paper identifies trans-splicing acceptor sites in TriTryps and shows similar chromatin organization across genes, with histone-containing complexes protecting these sites.

Histone H3 Ser10 phosphorylation occurs exclusively in replicative stages and peaks during mitosis in Trypanosoma cruzi

Experimental and Bioinformatic upgrade for genome-wide mapping of nucleosomes in Trypanosoma cruzi

The paper adapts and improves a nucleosome mapping method for Trypanosoma cruzi, emphasizing the importance of using a comprehensive genome reference and evaluating aligners for complex genomes.

DNA accessibility is not the primary determinant of chromatin-mediated gene regulation

The paper challenges the idea that DNA accessibility is the main factor in gene regulation by showing that accessibility varies between cells and does not strongly correlate with gene activity.

Transfer RNA Genes Affect Chromosome Structure and Function via Local Effects

This study shows that removing tRNA genes from a chromosome does not broadly disrupt chromosome folding but affects local nucleosome positioning and SMC protein binding, as well as centromere and heterochromatin clustering.