An age-preserving neuronal iSpheroid platform for modeling human aging and Alzheimer disease
Samhan Alsolami, Meiyan Wang, Thaís S. Sabedot, Upendra Singh, Brian Kirk, Lisa E. Mitchell, Melissa Hernandez, Nicholas J. Skvir, Chynna Bowman, Kotaro Oiwa, Ravi Agarwal, Marjan Mahmoudi, Michael S. Cuoco, Elise MacDonald, Samuel Cranston, , Fred H. Gage
This paper introduces an age-preserving neuronal iSpheroid platform that models human aging and Alzheimer's disease, revealing disease-associated metabolic changes and potential therapeutic targets.
bioRxiv · Oct 1, 2026 · PreprintNeuroscience