Author

Elise MacDonald

Boston UniversityORCID 0000-0001-6132-1391Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1

Frequent Co-Authors

George J. MurphyiD· 3 shared Nicholas J. SkviriD· 3 shared Samuel F. Cranston· 2 shared Todd W. DowreyiD· 2 shared Alexander TyshkovskiyiD· 1 shared Braden PateiD· 1 shared Brian Kirk· 1 shared Carly S. GoldeniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenomics

George J. MurphyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

GenomicsbioRxivPreprintOct 4, 2026

Disease-associated mutations directionally modulate epigenetic age in iPSC-derived tissues

Nicholas J. Skvir, Todd W. Dowrey, Samuel F. Cranston…·George J. Murphy

This study shows disease-associated mutations can directionally alter epigenetic age in iPSC-derived organoids, providing a model to study aging and disease interactions.

DOI 10.64898/2026.09.30.755445

humanDNA methylation

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NeurosciencebioRxivPreprintOct 1, 2026

An age-preserving neuronal iSpheroid platform for modeling human aging and Alzheimer disease

Samhan Alsolami, Meiyan Wang, Thaís S. Sabedot…·Fred H. Gage

This paper introduces an age-preserving neuronal iSpheroid platform that models human aging and Alzheimer's disease, revealing disease-associated metabolic changes and potential therapeutic targets.

DOI 10.64898/2026.09.30.755853

humannon-human primate

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Molecular BiologybioRxivPreprintOct 10, 2025

IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures

Todd W. Dowrey, Samuel F. Cranston, Nicholas J. Skvir…·George J. Murphy

The paper uses iPSC-derived neurons from centenarians to identify resilience signatures associated with longevity, showing enhanced stress response and specific transcriptional programs.

DOI 10.1101/2025.10.10.681757

humanbulk RNA-seq

𝕏 PostBluesky