Daniela Boassa

This paper introduces an age-preserving neuronal iSpheroid platform that models human aging and Alzheimer's disease, revealing disease-associated metabolic changes and potential therapeutic targets.

The paper uses in situ proteomics to show neuronal cilia have specialized nanodomains for extrasynaptic signaling, enriched in synaptic proteins and neurotransmitter receptors.

This paper introduces CaBLAM, a bioluminescent Ca2+ indicator with improved dynamic range and Ca2+ affinity, enabling high-resolution imaging of cellular activity in cultured neurons and in vivo.

This study investigates how mTOR inhibition reverses glioma-induced changes in excitatory neurons, showing effects on mRNA, dendritic spines, and neuronal activity.

This study shows that LRRK2 kinase activity causes centrosomal cohesion deficits through phosphorylated Rab10 and RILPL1 at centriolar subdistal appendages.

This study shows DOPAL promotes αSynuclein accumulation and impairs proteostasis in neuronal projections, contributing to Parkinson's disease progression.

The paper develops a genetic probe to label and image glutamatergic synaptic vesicles using 3D electron microscopy and deep learning.

CDeep3M-Preview allows users to test pre-trained neural networks on their data or public datasets via an online tool to improve reproducibility and biological insights.

The paper investigates the mechanisms and organization of clathrin transport and presynaptic targeting in neurons, revealing stable transport-packets and their role in synaptic clathrin organization.

This study describes the directed evolution of a split APEX peroxidase, demonstrating its reconstitution and functionality in different cellular contexts.