Nicholas J. Skvir

Disease-associated mutations directionally modulate epigenetic age in iPSC-derived tissues

This study shows disease-associated mutations can directionally alter epigenetic age in iPSC-derived organoids, providing a model to study aging and disease interactions.

An age-preserving neuronal iSpheroid platform for modeling human aging and Alzheimer disease

This paper introduces an age-preserving neuronal iSpheroid platform that models human aging and Alzheimer's disease, revealing disease-associated metabolic changes and potential therapeutic targets.

High resolution spatial profiling of the hematopoietic landscape of the murine lung

This paper creates a high-resolution spatial transcriptomic map of the murine lung's hematopoietic landscape, focusing on megakaryocytes and their interactions with vascular and stromal environments.

IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures

The paper uses iPSC-derived neurons from centenarians to identify resilience signatures associated with longevity, showing enhanced stress response and specific transcriptional programs.

A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring

The paper establishes a resource of iPSCs from centenarians and their offspring to study human longevity and resilience.

Expression of retrotransposons contributes to aging in Drosophila

This study investigates the role of retrotransposon expression and insertions in aging using Drosophila, finding that expression, not insertion, is linked to longevity.