Author

Brice Lapin

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1

Frequent Co-Authors

Frank BienaiméiD· 2 shared Jessica Vandensteen· 2 shared Manal MazloumiD· 2 shared Stéphanie DescroixiD· 2 shared Sylvie CoscoyiD· 2 shared Amandine AkaiD· 1 shared Amandine ViauiD· 1 shared Brigitte LelongtiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Frank BienaiméORCID

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2 papers

Recent·Most cited

Cilia to basement membrane signalling is a biomechanical driver of autosomal dominant polycystic kidney disease

Manal Mazloum, Brice Lapin, Rushdi Alghamdi, Jessica Vandensteen, Martine Burtin, Pascal Houillier, Lydie Cheval, Gilles Crambert, Vicky Scata, Camille Cohen, Christoph Schell, Michael Rehman, Amandine Aka, Karim Ourahmoun, Rui Benedito, , Frank Bienaimé

This study identifies biomechanical changes in the tubular basement membrane as drivers of cyst formation in ADPKD, linking cilia and polycystin-1 function.

Journal of Clinical Investigation · Jun 30, 2026Peer-reviewedPhysiology

Decoupling shear stress and pressure effects in the biomechanics of autosomal dominant polycystic kidney disease using a perfused kidney-on-chip.

Brice Lapin, Jessica Vandensteen, Giacomo Gropplero, Manal Mazloum, Frank Bienaimé, Stéphanie Descroix, Sylvie Coscoy

This study uses a kidney-on-chip model to decouple shear stress and pressure effects on tubule dilation in Pkd1-/- cells, revealing distinct mechanisms in different kidney cell types.

Acta Biomaterialia · Mar 13, 2025Peer-reviewedBiophysics