Frank Bienaimé

Non-HLA antibodies worsen the histological phenotype and prognosis of antibody mediated rejection in kidney allografts

This study shows non-HLA antibodies are linked to worse histology and graft outcomes in kidney transplant patients with antibody-mediated rejection, especially when combined with HLA-DSAs.

Cilia to basement membrane signalling is a biomechanical driver of autosomal dominant polycystic kidney disease

This study identifies biomechanical changes in the tubular basement membrane as drivers of cyst formation in ADPKD, linking cilia and polycystin-1 function.

A cilia-dependent inflammatory programme links bacterial detection to kidney disease

The paper shows primary cilia on kidney tubular cells initiate a fibro-inflammatory program in response to bacterial components, linking pathogen detection to kidney disease progression.

Decoupling shear stress and pressure effects in the biomechanics of autosomal dominant polycystic kidney disease using a perfused kidney-on-chip.

This study uses a kidney-on-chip model to decouple shear stress and pressure effects on tubule dilation in Pkd1-/- cells, revealing distinct mechanisms in different kidney cell types.