Author

Manal Mazloum

Centre National de la Recherche ScientifiqueORCID 0000-0001-9733-3781Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1

Frequent Co-Authors

Brice Lapin· 2 shared Frank BienaiméiD· 2 shared Jessica Vandensteen· 2 shared Stéphanie DescroixiD· 2 shared Sylvie CoscoyiD· 2 shared Amandine AkaiD· 1 shared Amandine ViauiD· 1 shared Brigitte LelongtiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Brice Lapin

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2 papers

Recent·Most cited

PhysiologyJournal of Clinical InvestigationPeer-reviewedJun 30, 2026

Cilia to basement membrane signalling is a biomechanical driver of autosomal dominant polycystic kidney disease

Manal Mazloum, Brice Lapin, Rushdi Alghamdi…·Frank Bienaimé

This study identifies biomechanical changes in the tubular basement membrane as drivers of cyst formation in ADPKD, linking cilia and polycystin-1 function.

3 citations

mouseexperimental assay

𝕏 PostBluesky

BiophysicsActa BiomaterialiaPeer-reviewedMar 13, 2025

Decoupling shear stress and pressure effects in the biomechanics of autosomal dominant polycystic kidney disease using a perfused kidney-on-chip.

Brice Lapin, Jessica Vandensteen, Giacomo Gropplero…·Sylvie Coscoy

This study uses a kidney-on-chip model to decouple shear stress and pressure effects on tubule dilation in Pkd1-/- cells, revealing distinct mechanisms in different kidney cell types.

9 citations

experimental assaycell type annotation

𝕏 PostBluesky