Leon C. D. Smyth

This study shows that reducing APOE4 in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and improves vascular function in a mouse model.

This paper develops an inducible genetic tool to study microglial states in development and disease, revealing their plasticity and functional roles.

The paper identifies cardiac glycosides as regulators of neuroinflammatory pathways in brain-barrier tissues using in vitro and ex vivo human models.