Author

Igor E. Koman

Ariel UniversityORCID 0000-0002-4860-9830Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Elimelech NesheriD· 2 shared Albert PinhasoviD· 1 shared Alfiya F. SafinaiD· 1 shared Andrei V. GudkoviD· 1 shared Andriy MarusykiD· 1 shared Anjana Edathil Kadangodan· 1 shared Bar Levi· 1 shared Benjamin G. Steinberg· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Elimelech NesherORCID

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2 papers

Recent·Most cited

Mega-frequency mutagenesis: generation of non-random precise mutations with extremely high frequency upon adaptation of cancer cells to drugs and stress

Victor Oleynik, Anjana Edathil Kadangodan, Valid Gahramanov, Subha Ranjan Das, Bar Levi, Julia A. Yaglom, К. И. Аношкин, Santosh Kumar, Benjamin G. Steinberg, Yitzhak Reizel, Pinchas Polonsky, Igor E. Koman, Vadim Levitt, Albert Pinhasov, Andriy Marusyk, , Michael Y. Sherman

The paper shows that cancer cells generate non-random, high-frequency mutations during drug adaptation, enriched near transcription factor binding sites.

bioRxiv · Feb 23, 2026 · PreprintCancer Biology

Transcription of Repeats Activates INterferon (TRAIN) in response to chromatin destabilization induced with anti-cancer small molecule

Katerina I. Leonova, Alfiya F. Safina, Elimelech Nesher, Poorva Sandlesh, Rachel N. Pratt, Catherine A. Burkhart, Britney Lipchick, Costakis G. Frangou, Igor E. Koman, Jianmin Wang, Кирсанов Кирилл Игоревич, Якубовская Марианна Геннадиевна, Andrei V. Gudkov, Katerina V. Gurova

The paper shows that chromatin destabilizing drugs like curaxin induce an interferon response (TRAIN) through repeat transcription, independent of p53 status, and may prevent cancer by eliminating epigenetically unstable cells.

bioRxiv · Jun 28, 2017 · PreprintMolecular Biology