Author

Poorva Sandlesh

Roswell Park Comprehensive Cancer CenterORCID 0000-0002-4775-7188Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Alfiya F. SafinaiD· 2 shared Jianmin WangiD· 2 shared Katerina V. GurovaiD· 2 shared Aimee B. StablewskiiD· 1 shared Andrei V. GudkoviD· 1 shared Britney Lipchick· 1 shared Catherine A. BurkhartiD· 1 shared Costakis G. FrangouiD· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersSystems Biology

Alfiya F. SafinaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

FACT-mediated maintenance of chromatin integrity during transcription is essential for viability of mammalian stem cells

Imon Goswami, Poorva Sandlesh, Aimee B. Stablewski, Ilya Toshkov, Alfiya F. Safina, Mikhail D. Magnitov, Jianmin Wang, Katerina V. Gurova

This study shows that FACT is essential for maintaining chromatin integrity during transcription in mammalian adult stem cells, and its loss leads to lethality due to stem cell failure.

bioRxiv · Jun 21, 2021 · PreprintSystems Biology

Transcription of Repeats Activates INterferon (TRAIN) in response to chromatin destabilization induced with anti-cancer small molecule

Katerina I. Leonova, Alfiya F. Safina, Elimelech Nesher, Poorva Sandlesh, Rachel N. Pratt, Catherine A. Burkhart, Britney Lipchick, Costakis G. Frangou, Igor E. Koman, Jianmin Wang, Кирсанов Кирилл Игоревич, Якубовская Марианна Геннадиевна, Andrei V. Gudkov, Katerina V. Gurova

The paper shows that chromatin destabilizing drugs like curaxin induce an interferon response (TRAIN) through repeat transcription, independent of p53 status, and may prevent cancer by eliminating epigenetically unstable cells.

bioRxiv · Jun 28, 2017 · PreprintMolecular Biology