Cancer BiologybioRxivPreprint
Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease
Mariam Lotfy Khaled, Yuan Ren, Ronak Kundalia…·Inna Smalley
This study identifies branched-chain keto acid accumulation in leptomeningeal disease CSF, showing immune suppression and neurodegeneration, and shows that reducing BCKA improves outcomes in mouse models.
2 citations