Author

Mariam Lotfy Khaled

Cairo UniversityORCID 0009-0009-2088-3801Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Hasan Alhaddad· 2 shared Inna SmalleyiD· 2 shared Oscar E. OspinaiD· 2 shared Yuan ReniD· 2 shared Brittany R. Evernden· 1 shared Brooke L. FridleyiD· 1 shared Ethan J. VallebuonaiD· 1 shared Fredrick L. Locke· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Hasan Alhaddad

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2 papers

Recent·Most cited

Cancer BiologyCell Reports MedicinePeer-reviewedJun 1, 2024

Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease

Hasan Alhaddad, Oscar E. Ospina, Mariam Lotfy Khaled…·Inna Smalley

This study uses spatial transcriptomics to identify a tumor-promoting role of meningeal stroma in melanoma leptomeningeal disease and shows that targeting SERPINA3 or its downstream pathway can restore drug sensitivity.

15 citations

humanspatial transcriptomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintDec 18, 2023

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease

Mariam Lotfy Khaled, Yuan Ren, Ronak Kundalia…·Inna Smalley

This study identifies branched-chain keto acid accumulation in leptomeningeal disease CSF, showing immune suppression and neurodegeneration, and shows that reducing BCKA improves outcomes in mouse models.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky