Intestinal-epithelial LSD1 controls cytoskeletal-mediated cell identity including goblet cell effector responses required for gut inflammatory and infectious diseases
Naveen Parmar, Kyle Burrows, Håvard T. Lindholm, Rosalie T. Zwiggelaar, Mara Martín-Alonso, Madeleine Fosslie, Bruce Vallance, John Arne Dahl, Colby Zaph, Menno J. Oudhoff
This study shows that intestinal-epithelial LSD1 deletion leads to increased pathogenesis in inflammatory and infectious disease models by impairing cytoskeletal organization and goblet cell effector responses.
bioRxiv · Jul 9, 2020Immunology