High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment
Wenxuan Du, Bryan Zhou, André Forjaz, Sarah M. Shin, Fan Wu, Ashleigh J. Crawford, Praful R. Nair, Adrian C. Johnston, Hoku West‐Foyle, Ashley Tang, Dongjoo Kim, Rong Fan, Ashley L Kiemen, Pei-Hsun Wu, Jude M. Phillip, , Denis Wirtz
This study identifies high-motility tumor-associated monocytes (TAMos) that drive macrophage infiltration and cancer cell proliferation via IL-6 and MAPK pathways, suggesting IL-6 as a therapeutic target.
bioRxiv · Jul 16, 2024 · PreprintImmunology